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NIH research grants (R series)
Need assistance with NIH research grants?
NIH research grants (R series) are intended to develop, support, and expand upon research programs for early career through senior investigators.
When applying for a R series grant, follow the most current NIH SF424 guidance, as well as any specific instructions in the funding opportunity announcement (FOA). Note: The FOA instructions always supersede the SF424 or standard page limitation guidance.
Also review additional NIH proposal guidance:
- Page limits for common sections
- Formatting guidelines
- Rules for text fields
- NIH Grants Policy Statement (to better understand the NIH, its grants process, and terms and conditions if the proposal is awarded)
Guidance on review and submission of the proposal is available within myRESEARCHpath. The grant manager should be contacted with questions (e.g., what documents transfer from SPS versus what is uploaded into grants.duke).
Support for NIH proposal development
Included below are grant writing toolkits developed by the SoM Office of Research Development and the Office of Campus Research Development (OCRD).
- Campus Schools/Provost Area - the Office of Campus Research Development (OCRD) provides additional proposal development support for NIH grant proposals to Duke campus-side faculty upon request.
- School of Medicine - explore how the SoM Office of Research Development supports NIH proposals.
Standard R grant templates and examples
Standard NIH R grants toolkit
Access the NIH R grant toolkit for guidance and templates to write a standard R grant. The R Grant Toolkit can be used for Parent R grant applications with R01, R21, or R03 Activity Codes.
Deadlines: NIH Standard deadlines apply.
The toolkit is revised annually to conform to any updates in the SF424 guidelines.
NIH R01 with clinical trial toolkit
Proposal resources
- NIH R award application tracking sheet and user guide
- NIH R award proposal development calendar template and user guide
- NIH R award writing tips
Proposal templates
- Abstract
- Authentication of Key Biological and Chemical Resources
- Biosketch (includes new form and guidance for proposals due on or after 1/25/2022)
- Budget Justification (Detailed)
- Consortium/Contractual Arrangements
- Data Management and Sharing Plan
- Equipment
- Facilities and Other Resources
- Facilities and Resources Repository (access boilerplate language and contacts for facilities and resources to potentially support the project)
- SoN Facilities and Other Resources (access only available to individuals in the School of Nursing)
- Introduction
- Letter of Support: Commitment to Provide a Resource
- Letter of Support: Consultant
- Letter of Support: Dean
- Letter of Support: Department Chair or Institute Director
- Modular Budget, Additional Narrative Justification
- Modular Budget, Consortium Justification
- Modular Budget, Personnel Justification
- Multiple PI Leadership Plan
- SoN Multiple PI Leadership Plan (access only available to individuals in the School of Nursing)
- Project Narrative
- References
- Research Strategy, Clinical Trial Required
- Resource Sharing Plan
- Select Agent Research
- Specific Aims
- Vertebrate Animals
NIH R01 without clinical trial toolkit
Proposal resources
- NIH R award application tracking sheet and user guide
- NIH R award proposal development calendar template and user guide
- NIH R award writing tips
Proposal templates
- Abstract
- Authentication of Key Biological and Chemical Resources
- Biosketch (includes new form and guidance for proposals due on or after 1/25/2022)
- Budget Justification (Detailed)
- Consortium/Contractual Arrangements
- Data Management and Sharing Plan
- Equipment
- Facilities and Other Resources
- Facilities and Resources Repository (access boilerplate language and contacts for facilities and resources to potentially support the project)
- SoN Facilities and Other Resources (access only available to individuals in the School of Nursing)
- Introduction
- Letter of Support: Commitment to Provide a Resource
- Letter of Support: Consultant
- Letter of Support: Dean
- Letter of Support: Department Chair or Institute Director
- Modular Budget, Additional Narrative Justification
- Modular Budget, Consortium Justification
- Modular Budget, Personnel Justification
- Multiple PI Leadership Plan
- SoN Multiple PI Leadership Plan (access only available to individuals in the School of Nursing)
- Project Narrative
- References
- Research Strategy, No Clinical Trial
- Resource Sharing Plan
- Select Agent Research
- Specific Aims
- Vertebrate Animals
NIH R21 with clinical trial toolkit
Proposal resources
- NIH R award application tracking sheet and user guide
- NIH R award proposal development calendar template and user guide
- NIH R award writing tips
Proposal templates
- Abstract
- Authentication of Key Biological and Chemical Resources
- Biosketch (includes new form and guidance for proposals due on or after 1/25/2022)
- Budget Justification (Detailed)
- Consortium/Contractual Arrangements
- Data Management and Sharing Plan
- Equipment
- Facilities and Other Resources
- Facilities and Resources Repository (access boilerplate language and contacts for facilities and resources to potentially support the project)
- SoN Facilities and Other Resources (access only available to individuals in the School of Nursing)
- Introduction
- Letter of Support: Commitment to Provide a Resource
- Letter of Support: Consultant
- Letter of Support: Dean
- Letter of Support: Department Chair or Institute Director
- Modular Budget, Consortium Justification
- Modular Budget, Personnel Justification
- Multiple PI Leadership Plan
- SoN Multiple PI Leadership Plan (access only available to individuals in the School of Nursing)
- Project Narrative
- References
- Research Strategy, Clinical Trial Required
- Resource Sharing Plan
- Select Agent Research
- Specific Aims
- Vertebrate Animals
NIH R21 without clinical trial toolkit
Proposal resources
- NIH R award application tracking sheet and user guide
- NIH R award proposal development calendar template and user guide
- NIH R award writing tips
Proposal templates
- Abstract
- Authentication of Key Biological and Chemical Resources
- Biosketch (includes new form and guidance for proposals due on or after 1/25/2022)
- Budget Justification (Detailed)
- Consortium/Contractual Arrangements
- Data Management and Sharing Plan
- Equipment
- Facilities and Other Resources
- Facilities and Resources Repository (access boilerplate language and contacts for facilities and resources to potentially support the project)
- SoN Facilities and Other Resources (access only available to individuals in the School of Nursing)
- Introduction
- Letter of Support: Commitment to Provide a Resource
- Letter of Support: Consultant
- Letter of Support: Dean
- Letter of Support: Department Chair or Institute Director
- Modular Budget, Consortium Justification
- Modular Budget, Personnel Justification
- Multiple PI Leadership Plan
- SoN Multiple PI Leadership Plan (access only available to individuals in the School of Nursing)
- Project Narrative
- References
- Research Strategy, No Clinical Trial
- Resource Sharing Plan
- Select Agent Research
- Specific Aims
- Vertebrate Animals
NIH R grants Human Subjects and Clinical Trials attachments
- Human Subjects Study fillable form (download to view); annotated fillable form (see p. 31)
- Study Record: Human Subjects and Clinical Trials Information fillable form (download to view); annotated fillable form (see p. 32-39)
- Availability of Investigational Product (IP) and Investigational New Drug (IND)/Investigational Device Exemption (IDE) Status
- Data and Safety Monitoring Plan
- Delayed Onset Justification
- Dissemination Plan
- Human Specimens and/or Data Not Considered Human Subjects Research
- Inclusion of Individuals across the Lifespan
- Inclusion of Women and Minorities
- Other Requested Information
- Overall Structure of the Study Team
- Protection of Human Subjects
- Recruitment and Retention Plan
- Recruitment and Retention Plan, if using existing dataset/resource
- Single IRB Plan
- Statistical Design and Power
- Study Timeline
Other R grant templates
NIH TRA R01 toolkit
Funding opportunity through NIH’s High-Risk, High-Reward Research program, which supports exceptionally creative scientists pursuing highly innovative research with the potential for broad impact in biomedical, behavioral, or social sciences within the NIH mission.
deadline: 9/1/23
NIH SRD R01 toolkit
(PAR-23-112) The NIH-wide initiative on Addressing the Impact of Structural Racism and Discrimination (SRD) on Minority Health and Health Disparities is available through an R01 activity code to support intervention research to address the impact of SRD on minority health and health disparities.
Upcoming Deadlines: 10/10/23, 1/7/24 (AIDS)
NIH ReWARD R01 toolkit
(PAR-23-122) The NIH-wide initiative on Research With Activities Related to Diversity (ReWARD) through an R01 activity code supports health-related research of scientists who are making a significant contribution to Diversity, Equity, Inclusion, and Accessibility (DEIA) and who have no current NIH research project grant funding. The ReWARD program provides funding for both the scientific research and the DEIA activities of investigators.
Upcoming Deadlines: 10/5/23, 1/7/24 (AIDS)
NIH/NIAID R25 toolkit
The NIH Research Education Program (R25) supports research education activities that complement other formal training programs in the mission areas of the NIH.
(PAR-22-134) This NIAID-focused R25 program will support creative educational activities with a primary focus on: (1) Courses for Skills Development, (2) Research Experiences, and (3) Mentoring Activities targeted to undergraduates, graduate students, postdocs, and/or early-career faculty program participants.
Access the NIH/NIAID R25 toolkit
Upcoming Deadlines: 7/25/23 or 10/10/23 (AIDS)
NIH R25 SEPA toolkit
The NIH Research Education Program (R25) supports research education activities that complement other formal training programs in the mission areas of the NIH.
(PAR-23-137) Science Education Partnership Award (SEPA) R25 program is to support educational activities that encourage pre-college students (pre-kindergarten to grade 12) from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies in STEM.
Upcoming Deadlines: 7/14/23 or 6/7/24
NIH/NIGMS R35 MIRA ESI toolkit
(PAR-23-145) The Maximizing Investigators' Research Award (MIRA) under the R35 activity code provides support for a program of research in an early stage investigator's (ESI) laboratory that falls within the mission of NIGMS. For the purpose of this opportunity, a program of research is a collection of projects in the investigator's lab that are relevant to the mission of NIGMS. The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding.
Access the NIH/NIGMS R35 MIRA ESI toolkit
Upcoming Deadline: 10/3/23