Customize Your Path

Select all of the following that apply to you and your research project to tailor the topics and resources displayed. Your selections will persist every time you access the site on the same device, until you change or reset the selections.
Your role:
Project inclusions:
Project sponsor or funding:
(seeking funding from or have already secured funding from)
Project managed by:
Subtopic

NIH research grants (R series)

Need assistance with NIH research grants?

NIH research grants (R series) are intended to develop, support, and expand upon research programs for early career through senior investigators.   

When applying for a R series grant, follow the most current NIH SF424 guidance, as well as any specific instructions in the funding opportunity announcement (FOA).  Note: The FOA instructions always supersede the SF424 or standard page limitation guidance.

Also review additional NIH proposal guidance:

Guidance on review and submission of the proposal is available within myRESEARCHpath. The grant manager should be contacted with questions (e.g., what documents transfer from SPS versus what is uploaded into grants.duke).

Support for NIH proposal development

Included below are grant writing toolkits developed by the SoM Office of Research Development and the Office of Campus Research Development (OCRD). 

Standard R grant toolkits, templates, and examples

See below for templates and examples for commonly required sections of research grants. Consult the FOA for specific section requirements that apply to that funding mechanism.
Standard NIH R Grant toolkit

Access the NIH R Grant toolkit for guidance and templates to write a standard R grant. The R Grant Toolkit can be used for Parent R grant applications with R01, R21, or R03 Activity Codes.

Deadlines: NIH Standard deadlines apply.

The toolkit is revised annually to conform to any updates in the SF424 guidelines.

NIH R01 with clinical trial toolkit
NIH R01 without clinical trial toolkit
NIH R21 with clinical trial toolkit
NIH R21 without clinical trial toolkit
NIH R grants Human Subjects and Clinical Trials attachments

Other R Grant toolkits

NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional)

NIH Director’s Transformative Research Awards (R01 Clinical Trial Optional) (NIH TRA R01) (RFA-RM-24-004) is a High-Risk, High-Reward Research Funding opportunity program, which supports exceptionally creative scientists pursuing highly innovative research with the potential for broad impact in biomedical, behavioral, or social sciences within the NIH mission.

Upcoming (anticipated) deadline: Sept. 2025

** This toolkit is updated annually.**

NIH Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional)

NIH Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional) (NIH SRD R01) (PAR-23-112) The NIH-wide initiative on Addressing the Impact of Structural Racism and Discrimination (SRD) on Minority Health and Health Disparities is available through an R01 activity code to support intervention research to address the impact of SRD on minority health and health disparities.

Upcoming Deadlines: 10/9/2024, 1/7/2025 (AIDS)

NIH NIAID Research Education Program (R25 Clinical Trial Not Allowed)

The NIH NIAID Research Education Program (R25 Clinical Trial Not Allowed) (NIAID R25) (PAR-22-134) supports research education activities that complement other formal training programs in the mission areas of the NIH. 

This NIAID-focused R25 program will support creative educational activities with a primary focus on: (1) Courses for Skills Development, (2) Research Experiences, and (3) Mentoring Activities targeted to undergraduates, graduate students, postdocs, and/or early-career faculty program participants.

Upcoming Deadlines: 7/25/2024 or 10/9/2024 (AIDS)

NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)

The NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed) (R25 SEPA) (PAR-23-137) supports research education activities that complement other formal training programs in the mission areas of the NIH. 

The SEPA R25 program is to support educational activities that encourage pre-college students (pre-kindergarten to grade 12) from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies in STEM.

Upcoming Deadline: 6/6/2025

NIH Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI) (R35 - Clinical Trial Optional)

The NIH Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI) (R35 - Clinical Trial Optional) (NIGMS R35 MIRA ESI) (PAR-23-145) provides support for a program of research in an early-stage investigator's (ESI) laboratory that falls within the mission of NIGMS. For the purpose of this opportunity, a program of research is a collection of projects in the investigator's lab that are relevant to the mission of NIGMS. The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding.

Upcoming Deadline: 10/3/2024